Journal of Pathology and Translational Medicine

Brief Case Report

Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus: Ji Eun Choi, Sang Jae Noh, Jong Jin Sung, Woo Sung Moon; Korean J Pathol. 2013;47(5):489-491. Published online October 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.489

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Citations

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Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia
Martin Philipp Dieterle, Ayman Husari, Sophie Nicole Prozmann, Hendrik Wiethoff, Albrecht Stenzinger, Manuel Röhrich, Uwe Pfeiffer, Wolfgang Rüdiger Kießling, Helena Engel, Harald Sourij, Thorsten Steinberg, Pascal Tomakidi, Stefan Kopf, Julia Szendroedi
Biomedicines.2023; 11(6): 1732. CrossRef
Postprandial hypoglycemia after upper gastrointestinal tract surgery: prevalence and pathophysiology (part 1)
M. Yu. Yukina, M. O. Chernova, E. A. Troshina, V. V. Evdoshenko, N. M. Platonova
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Concurrent Adult-Onset Diffuse β-Cell Nesidioblastosis and Pancreatic Neuroendocrine Tumor: A Case Report and Review of the Literature
Mushfig Orujov, Keith K. Lai, Catherine L. Forse
International Journal of Surgical Pathology.2019; 27(8): 912. CrossRef
Nesidioblastosis in an Adult with Short Gut Syndrome and Type 2 Diabetes
Mimi Wong, Luke Conway, Caroline Cooper, Ashim Sinha, Nirjhar Nandi
AACE Clinical Case Reports.2019; 5(6): e375. CrossRef
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Minerva K. Fahmy, Hayam G. Sayyed, Eman A. Abd Elrahim, Rana T.A. Farag
Alexandria Journal of Medicine.2018; 54(2): 129. CrossRef
Diagnostic Performance of 48-Hour Fasting Test and Insulin Surrogates in Patients With Suspected Insulinoma
Keijiro Ueda, Ken Kawabe, Lingaku Lee, Yuichi Tachibana, Nao Fujimori, Hisato Igarashi, Yoshinao Oda, Robert T. Jensen, Ryoichi Takayanagi, Tetsuhide Ito
Pancreas.2017; 46(4): 476. CrossRef
Nesidioblastosis (diagnosis, surgical treatment)
A. G. Kriger, A. V. Smirnov, D. V. Kalinin, A. V. Glotov, S. V. Berelavichus, G. I. Konyaeva, A. N. Lebedeva, N. A. Karel’skaya, V. N. Tsygankov
Khirurgiya. Zhurnal im. N.I. Pirogova.2015; (10): 16. CrossRef
A Rare Complication of Gastric Bypass (Weight Loss) Surgery
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International Journal of Surgical Pathology.2015; 23(1): 68. CrossRef

Original Article

Expression of Cortactin and Focal Adhesion Kinase in Colorectal Adenocarcinoma: Correlation with Clinicopathologic Parameters and Their Prognostic Implication: Yo Na Kim, Ji Eun Choi, Jun Sang Bae, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Ho Sung Park; Korean J Pathol. 2012;46(5):454-462. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.454

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Abstract PDF

Background

Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration.

Methods

The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance.

Results

Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival.

Conclusions

Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.

Citations

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Cancer Cell International.2021;[Epub] CrossRef
PZR promotes metastasis of colorectal cancer through increasing FAK and Src phosphorylation
Dan Tan, Wenpeng Zhang, Yu Tao, Yesseyeva Galiya, Mingliang Wang
Acta Biochimica et Biophysica Sinica.2019; 51(4): 356. CrossRef
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Cancer Cell International.2019;[Epub] CrossRef
Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway
Xiaojian Zhang, Kun Liu, Tao Zhang, Zhenlei Wang, Xuan Qin, Xiaoqian Jing, Haoxuan Wu, Xiaopin Ji, Yonggang He, Ren Zhao
Oncotarget.2017; 8(1): 1541. CrossRef
Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis
Xiao-Qing Zeng, Na Li, Li-Li Ma, Yu-Jen Tseng, Nai-Qing Zhao, Shi-Yao Chen, Han-Chung Wu
PLOS ONE.2016; 11(9): e0162666. CrossRef
Regulators of Actin Dynamics in Gastrointestinal Tract Tumors
Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald
Gastroenterology Research and Practice.2015; 2015: 1. CrossRef

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